Organization of the social cognition network predicts future depression and interpersonal impairment: a prospective family-based study.

ABSTRACT: Deficits in social cognition and functioning are common in major depressive disorder (MDD). Still, no study into the pathophysiology of MDD has examined the social cognition-related neural pathways through which familial risk for MDD leads to depression and interpersonal impairments. Using resting-state fMRI, we applied a graph theoretical analysis to quantify the influence of nodes within the fronto-temporo-parietal cortical social cognition network in 108 generation 2 and generation 3 offspring at high and low-risk for MDD, defined by the presence or absence, respectively, of moderate to severe MDD in generation 1. New MDD episodes, future depressive symptoms, and interpersonal impairments were tested for associations with social cognition nodal influence, using regression analyses appli

SUBMITTER: Abraham E 

PROVIDER: S-EPMC8674240 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature