Stress-induced generalization of negative memories is mediated by an extended hippocampal circuit.

ABSTRACT: Memories of negative experiences exert important control of behavior in the face of actual or anticipated threat. Sometimes, however, this control extends to non-threatening situations, a phenomenon known as overgeneralization of negative memories. Overgeneralization is a reliable cognitive phenotype of major depressive disorder, generalized anxiety disorder, and post-traumatic stress disorder. We therefore sought to develop an animal model to study stress-induced generalization of negative memories (SIG) and determine its dependence on the episodic-like memory circuit. We found that male and female mice, which were trained to differentiate a threatening from neutral context, exhibited robust SIG in response to subsequent social stress. Using chemogenetic circuit manipulations during memor

SUBMITTER: Ren LY 

PROVIDER: S-EPMC8674250 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature