Evaluating the evidence for sex differences: a scoping review of human neuroimaging in psychopharmacology research.

ABSTRACT: Although sex differences in psychiatric disorders abound, few neuropsychopharmacology (NPP) studies consider sex as a biological variable (SABV). We conducted a scoping review of this literature in humans by systematically searching PubMed to identify peer-reviewed journal articles published before March 2020 that (1) studied FDA-approved medications used to treat psychiatric disorders (or related symptoms) and (2) adequately evaluated sex differences using in vivo neuroimaging methodologies. Of the 251 NPP studies that included both sexes and considered SABV in analyses, 80% used methodologies that eliminated the effect of sex (e.g., by including sex as a covariate to control for its effect). Only 20% (50 studies) adequately evaluated sex differences either by testing for an interaction i

SUBMITTER: Duffy KA 

PROVIDER: S-EPMC8674314 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature