Directly recruited GATA6 + peritoneal cavity macrophages contribute to the repair of intestinal serosal injury.

ABSTRACT: Recruitment of bone marrow derived monocytes via bloodstream and their subsequent conversion to CX3CR1⁺ macrophages in response to intestinal injury is dependent on CCR2, Nr4a1, and the microbiome. This process is critical for proper tissue repair; however, GATA6⁺ peritoneal cavity macrophages might represent an alternative, more readily available source of mature and functional myeloid cells at the damaged intestinal locations. Here we show, using spinning-disk confocal microscopy, that large F4/80^hiGATA6⁺ peritoneal cavity macrophages promptly accumulate at damaged intestinal sites upon intestinal thermal injury and upon dextran sodium sulfate induced colitis in mice via a direct route from the peritoneal cavity. In contrast to bloodstream deri

SUBMITTER: Honda M 

PROVIDER: S-EPMC8674319 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature