Genomic analyses of human adenoviruses unravel novel recombinant genotypes associated with severe infections in pediatric patients.

ABSTRACT: Human adenoviruses (HAdVs) are highly contagious pathogens of clinical importance, especially among the pediatric population. Studies on comparative viral genomic analysis of cases associated with severe and mild infections due to HAdV are limited. Using whole-genome sequencing (WGS), we investigated whether there were any differences between circulating HAdV strains associated with severe infections (meningitis, sepsis, convulsion, sudden infant death syndrome, death, and hospitalization) and mild clinical presentations in pediatric patients hospitalized between the years 1998 and 2017 in a tertiary care hospital group in Bern, Switzerland covering a population base of approx. 2 million inhabitants. The HAdV species implicated in causing severe infections in this study included HAdV speci

SUBMITTER: Akello JO 

PROVIDER: S-EPMC8674331 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature