MHC Class II Presentation Is Affected by Polymorphism in the H2-Ob Gene and Additional Loci.

ABSTRACT: Pathogen-derived peptides are loaded on MHC class II (MHCII) and presented to CD4⁺ T cells for their activation. Peptide loading of MHCII occurs in specialized endosomal compartments and is controlled by the nonclassical MHCII molecules H2-M and H2-O, which are both constitutive αβ heterodimers. H2-M catalyzes MHCII peptide loading, whereas H2-O modulates H2-M activity by acting as an MHCII mimic. Recently, we discovered that the H2-Ob allele inherited by retrovirus-resistant I/LnJ mice results in nonfunctional H2-O. I/LnJ H2-O binds to but does not inhibit H2-M. Compared with H2-Oβ from virus-susceptible mice, H2-Oβ from I/LnJ mice has four unique amino acid substitutions, three in the Ig domain and one in the cytoplasmic tail. In this study we show that the three amino

SUBMITTER: Cullum E 

PROVIDER: S-EPMC8674376 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature