Diagnosing capillary leak in critically ill patients: development of an innovative scoring instrument for non-invasive detection.

ABSTRACT:

Background

The concomitant occurrence of the symptoms intravascular hypovolemia, peripheral edema and hemodynamic instability is typically named Capillary Leak Syndrome (CLS) and often occurs in surgical critical ill patients. However, neither a unitary definition nor standardized diagnostic criteria exist so far. We aimed to investigate common characteristics of this phenomenon with a subsequent scoring system, determining whether CLS contributes to mortality.

Methods

We conducted this single-center, observational, multidisciplinary, prospective trial in two separately run surgical ICUs of a tertiary academic medical center. 200 surgical patients admitted to the ICU and 30 healthy volunteers were included. Patients were clinically diagnosed as CLS or No-CLS group (each N = 

SUBMITTER: Wollborn J 

PROVIDER: S-EPMC8674404 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature