Ischemic Heart Disease Selectively Modifies the Right Atrial Appendage Transcriptome.

ABSTRACT: Background: Although many pathological changes have been associated with ischemic heart disease (IHD), molecular-level alterations specific to the ischemic myocardium and their potential to reflect disease severity or therapeutic outcome remain unclear. Currently, diagnosis occurs relatively late and evaluating disease severity is largely based on clinical symptoms, various imaging modalities, or the determination of risk factors. This study aims to identify IHD-associated signature RNAs from the atrial myocardium and evaluate their ability to reflect disease severity or cardiac surgery outcomes. Methods and Results: We collected right atrial appendage (RAA) biopsies from 40 patients with invasive coronary angiography (ICA)-positive IHD undergoing coronary artery bypass surge

SUBMITTER: Mulari S 

PROVIDER: S-EPMC8674465 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature