3D Visualization of the Dynamic Bidirectional Talk Between ER/PR and Her2 Pathways.

ABSTRACT: Background: Extensive amounts of archived formalin fixed paraffin embedded (FFPE) human tumor tissues are the ultimate resource to investigate signaling network underlying tumorigenesis in human. Yet, their usage is severely limited for lacking of suitable protein techniques. In this study, a quantitative, objective, absolute, and high throughput immunoblot method, quantitative dot blot (QDB), was explored to address this issue by investigating the putative relationship between estrogen receptor (ER)/progesterone receptor (PR) and human epidermal growth factor receptor 2 (Her2) pathways in breast cancer tumorigenesis. Methods: In this descriptive observational retrospective study, ER, PR, Her2, and Ki67 protein levels were measured absolutely and quantitatively in 852 FFPE br

SUBMITTER: Lyv J 

PROVIDER: S-EPMC8674721 | biostudies-literature | 2021 Jan-Dec

REPOSITORIES: biostudies-literature