Association Between Antimicrobial Prophylaxis With Double-Dose Cefuroxime and Surgical Site Infections in Patients Weighing 80 kg or More.

ABSTRACT:

Importance

Many guidelines recommend a weight-adopted dose increase of cefuroxime for surgical antimicrobial prophylaxis (SAP). However, the evidence that this approach is associated with lower rates of surgical site infection (SSI) is limited.

Objective

To assess whether double-dose cefuroxime SAP was associated with a decreased SSI rate in patients weighing at least 80 kg.

Design, setting, and participants

This cohort study included adult patients (>18 years) weighing at least 80 kg who underwent 9 major surgical procedures with a cefuroxime SAP administration from the Swissnoso SSI surveillance system between January 2015 and December 2019 at 142 Swiss hospitals. The follow-up was 30 days for all surgical procedures and 1 year for implant-related operations.

Exp

SUBMITTER: Sommerstein R 

PROVIDER: S-EPMC8674749 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature