Ontology highlight
ABSTRACT:
SUBMITTER: Rodel HE
PROVIDER: S-EPMC8674758 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Rodel Hylton E HE Ferreira Isabella A T M IATM Ziegler Carly G K CGK Ganga Yashica Y Bernstein Mallory M Hwa Shi-Hsia SH Nargan Kievershen K Lustig Gila G Kaplan Gilla G Noursadeghi Mahdad M Shalek Alex K AK Steyn Adrie J C AJC Sigal Alex A
Frontiers in microbiology 20211202
<i>Mycobacterium tuberculosis</i> (Mtb) bacilli readily aggregate. We previously reported that Mtb aggregates lead to phagocyte death and subsequent efficient replication in the dead infected cells. Here, we examined the transcriptional response of human monocyte derived macrophages to phagocytosis of aggregated Mtb relative to phagocytosis of non-aggregated single or multiple bacilli. Infection with aggregated Mtb led to an early upregulation of pro-inflammatory associated genes and enhanced TN ...[more]