Association of Complement and MAPK Activation With SARS-CoV-2-Associated Myocardial Inflammation.

ABSTRACT:

Importance

Myocardial injury is a common feature of patients with SARS-CoV-2 infection. However, the cardiac inflammatory processes associated with SARS-CoV-2 infection are not completely understood.

Objective

To investigate the inflammatory cardiac phenotype associated with SARS-CoV-2 infection compared with viral myocarditis, immune-mediated myocarditis, and noninflammatory cardiomyopathy by integrating histologic, transcriptomic, and proteomic profiling.

Design, setting, and participants

This case series was a cooperative study between the Ludwig Maximilian University Hospital Munich and the Cardiopathology Referral Center at the University of Tübingen in Germany. A cohort of 19 patients with suspected myocarditis was examined; of those, 5 patients were hospitalize

SUBMITTER: Weckbach LT 

PROVIDER: S-EPMC8674808 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature