Regulatory T Cells as Predictors of Clinical Course in Hospitalised COVID-19 Patients.

ABSTRACT:

Background

The host immune response has a prominent role in the progression and outcome of SARS-CoV-2 infection. Lymphopenia has been described as an important feature of SARS-CoV-2 infection and has been associated with severe disease manifestation. Lymphocyte dysregulation and hyper-inflammation have been shown to be associated with a more severe clinical course; however, a T cell subpopulation whose dysfunction correlate with disease progression has yet to be identify.

Methods

We performed an immuno-phenotypic analysis of T cell sub-populations in peripheral blood from patients affected by different severity of COVID-19 (n=60) and undergoing a different clinical evolution. Clinical severity was established based on a modified WHO score considering both ventilation support

SUBMITTER: Caldrer S 

PROVIDER: S-EPMC8674838 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature