Real-world corticosteroid use in severe pneumonia: a propensity-score-matched study.

ABSTRACT:

Background

Community-acquired pneumonia (CAP) is a leading cause of morbidity and mortality worldwide despite correct antibiotic use. Corticosteroids have long been evaluated as a treatment option, but heterogeneous effects on survival have precluded their widespread implementation. We aimed to evaluate whether corticosteroids might improve clinical outcomes in patients with severe CAP and high inflammatory responses.

Study design and methods

We analyzed two prospective observational cohorts of patients with CAP in Barcelona and Rome who were admitted to intensive care with a high inflammatory response. Propensity score (PS) matching was used to obtain balance among the baseline variables in both groups, and we excluded patients with viral pneumonia or who received hydrocort

SUBMITTER: Ceccato A 

PROVIDER: S-EPMC8674860 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature