Positive end-expiratory pressure in COVID-19 acute respiratory distress syndrome: the heterogeneous effects.

ABSTRACT:

Background

We hypothesized that as CARDS may present different pathophysiological features than classic ARDS, the application of high levels of end-expiratory pressure is questionable. Our first aim was to investigate the effects of 5-15 cmH₂O of PEEP on partitioned respiratory mechanics, gas exchange and dead space; secondly, we investigated whether respiratory system compliance and severity of hypoxemia could affect the response to PEEP on partitioned respiratory mechanics, gas exchange and dead space, dividing the population according to the median value of respiratory system compliance and oxygenation. Thirdly, we explored the effects of an additional PEEP selected according to the Empirical PEEP-FiO₂ table of the EPVent-2 study on partitioned respiratory

SUBMITTER: Chiumello D 

PROVIDER: S-EPMC8674862 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature