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In Vitro and In Silico Characterization of Kurarinone as a Dopamine D_1A Receptor Antagonist and D_2L and D₄ Receptor Agonist.

ABSTRACT: Alterations in the expression and/or activity of brain G-protein-coupled receptors (GPCRs) such as dopamine D₁R, D_2LR, D₃R, and D₄R, vasopressin V_1AR, and serotonin 5-HT_1AR are noted in various neurodegenerative diseases (NDDs). Since studies have indicated that flavonoids can target brain GPCRs and provide neuroprotection via inhibition of monoamine oxidases (hMAOs), our study explored the functional role of kurarinone, an abundant lavandulated flavonoid in Sophora flavescens, on dopamine receptor subtypes, V_1AR, 5-HT_1AR, and hMAOs. Radioligand binding assays revealed considerable binding of kurarinone on D₁R, D_2LR, and D₄R. Functional GPCR assays unfolded the co

SUBMITTER: Prajapati R

PROVIDER: S-EPMC8674921 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature

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In Vitro and In Silico Characterization of Kurarinone as a Dopamine D_1A Receptor Antagonist and D_2L and D₄ Receptor Agonist.

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Dataset Information

In Vitro and In Silico Characterization of Kurarinone as a Dopamine D1A Receptor Antagonist and D2L and D4 Receptor Agonist.

OmicsDI is part of the ELIXIR infrastructure

Tweets

In Vitro and In Silico Characterization of Kurarinone as a Dopamine D_1A Receptor Antagonist and D_2L and D₄ Receptor Agonist.