Fornix white matter microstructure differentially predicts false recollection rates in older and younger adults.

ABSTRACT: Healthy aging is accompanied by increased false remembering in addition to reduced successful remembering in older adults. Neuroimaging studies implicate age-related differences in the involvement of medial temporal lobe and fronto-parietal regions in mediating highly confident false recollection. However, no studies have directly examined the relationship between white matter microstructure and false recollection in younger and older adults. Using diffusion-weighted imaging and probabilistic tractography, we examined how white matter microstructure within tracts connecting the hippocampus and the fronto-parietal retrieval network contribute to false recollection rates in healthy younger and older adults. We found only white matter microstructure within the fornix contributed to false reco

SUBMITTER: Chamberlain JD 

PROVIDER: S-EPMC8674925 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature