The nanotopography of SiO₂ particles impacts the selectivity and 3D fold of bound allergens.

ABSTRACT: A detailed description of the changes that occur during the formation of protein corona represents a fundamental question in nanoscience, given that it not only impacts the behaviour of nanoparticles but also affects the bound proteins. Relevant questions include whether proteins selectively bind particles, whether a specific orientation is preferred for binding, and whether particle binding leads to a modulation of their 3D fold. For allergens, it is important to answer these questions given that all these effects can modify the allergenic response of atopic individuals. These potential impacts on the bound allergen are closely related to the specific properties of the involved nanoparticles. One important property influencing the formation of protein corona is the nanotopography of the p

SUBMITTER: Mills-Goodlet R 

PROVIDER: S-EPMC8675021 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature