Pragmatic trials of pain therapies: a systematic review of methods.

ABSTRACT:

Abstract

Pragmatic randomised clinical trials aim to directly inform clinical or health policy decision making. Here, we systematically review methods and design of pragmatic trials of pain therapies to examine methods, identify common challenges, and areas for improvement. Seven databases were searched for pragmatic randomised controlled clinical trials that assessed pain treatment in a clinical population of adults reporting pain. All screening steps and data extractions were performed twice. Data were synthesised descriptively, and correlation analyses between prespecified trial features and PRECIS-2 (PRagmatic-Explanatory Continuum Indicator Summary 2) ratings and attrition were performed. Protocol registration: PROSPERO-ID CRD42020178954. Of 57 included trials, only 21% assess

SUBMITTER: Hohenschurz-Schmidt D 

PROVIDER: S-EPMC8675058 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature