Effects of chemogenetic manipulation of the nucleus accumbens core in male C57BL/6J mice.

ABSTRACT: Binge drinking is a widespread public health concern with limited effective treatment options. To better select pharmaceutical targets, it is imperative to expand our knowledge of the underlying neural mechanisms involved in binge drinking. Our previous experiments in C57BL/6J female mice found that increasing activity in the nucleus accumbens (NAc) core using excitatory Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) reduced binge-like drinking. These results differed from what has been found in males; however, it is unclear whether differences in experimental procedures or sex underlie these discrepancies. We matched the conditions used in our female study and asked whether bidirectional manipulation of NAc core activity has different effects on binge-like drinking i

SUBMITTER: Townsley KG 

PROVIDER: S-EPMC8675149 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature