Metformin Use and Risk of Asthma Exacerbation Among Asthma Patients with Glycemic Dysfunction.

ABSTRACT:

Background

Diabetes is associated with worse asthma morbidity. Metformin, which treats diabetes, may have a role among patients with asthma and glycemic dysfunction.

Objective

To determine the association between metformin use and asthma exacerbations among patients with diabetes.

Methods

We queried the Johns Hopkins electronic health record from April 1, 2013, to May 31, 2018. Adults with asthma and diabetes were followed from first hemoglobin A1c (HbA1c) test to an asthma-related systemic corticosteroid prescription, emergency department (ED) visit, or hospitalization. Multivariable Cox models estimated time to each outcome associated with metformin use, modeled as either time-invariant (status at HbA1c testing) or time-dependent (based on fill data). Mediation of r

SUBMITTER: Wu TD 

PROVIDER: S-EPMC8675235 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature