Common and gender-specific associations with cocaine use on gray matter volume: Data from the ENIGMA addiction working group.

ABSTRACT: Gray matter volume (GMV) in frontal cortical and limbic regions is susceptible to cocaine-associated reductions in cocaine-dependent individuals (CD) and is negatively associated with duration of cocaine use. Gender differences in CD individuals have been reported clinically and in the context of neural responses to cue-induced craving and stress reactivity. The variability of GMV in select brain areas between men and women (e.g., limbic regions) underscores the importance of exploring interaction effects between gender and cocaine dependence on brain structure. Therefore, voxel-based morphometry data derived from the ENIGMA Addiction Consortium were used to investigate potential gender differences in GMV in CD individuals compared to matched controls (CTL). T1-weighted MRI scans and clini

SUBMITTER: Rabin RA 

PROVIDER: S-EPMC8675419 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature