Cortical thickness across the lifespan: Data from 17,075 healthy individuals aged 3-90 years.

ABSTRACT: Delineating the association of age and cortical thickness in healthy individuals is critical given the association of cortical thickness with cognition and behavior. Previous research has shown that robust estimates of the association between age and brain morphometry require large-scale studies. In response, we used cross-sectional data from 17,075 individuals aged 3-90 years from the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) Consortium to infer age-related changes in cortical thickness. We used fractional polynomial (FP) regression to quantify the association between age and cortical thickness, and we computed normalized growth centiles using the parametric Lambda, Mu, and Sigma method. Interindividual variability was estimated using meta-analysis and one-way analysi

SUBMITTER: Frangou S 

PROVIDER: S-EPMC8675431 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature