Enhanced hepatic respiratory capacity and altered lipid metabolism support metabolic homeostasis during short-term hypoxic stress.

ABSTRACT:

Background

Tissue hypoxia is a key feature of several endemic hepatic diseases, including alcoholic and non-alcoholic fatty liver disease, and organ failure. Hypoxia imposes a severe metabolic challenge on the liver, potentially disrupting its capacity to carry out essential functions including fuel storage and the integration of lipid metabolism at the whole-body level. Mitochondrial respiratory function is understood to be critical in mediating the hepatic hypoxic response, yet the time-dependent nature of this response and the role of the respiratory chain in this remain unclear.

Results

Here, we report that hepatic respiratory capacity is enhanced following short-term exposure to hypoxia (2 days, 10% O₂) and is associated with increased abundance of the respir

SUBMITTER: O'Brien KA 

PROVIDER: S-EPMC8675474 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature