Association of three micro-RNA gene polymorphisms with the risk of cervical cancer: a meta-analysis and systematic review.

ABSTRACT:

Objective

Regulation of single nucleotide polymorphisms (SNP) in micro-RNA (miRNA) on the host cells may be one of the most important factors influencing the occurrence of cervical cancer based on the prevalence of HPV infection and the development of cervical cancer. In order to explore the contribution of miRNA polymorphism to the occurrence and development of cervical cancer, we conducted an analytical study.

Methods

We selected the polymorphisms of three widely studied miRNAs (miRNA-146a rs2910164, miRNA-499 rs3746444, and miRNA-196a2 rs11614913). Then, we conducted a meta-analysis (for the first time) to investigate their susceptibility to cervical cancer. Case control studies on the correlation between these three miRNAs and cervical cancer susceptibility were investig

SUBMITTER: Xu J 

PROVIDER: S-EPMC8675500 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature