Ebola vaccine-induced protection in nonhuman primates correlates with antibody specificity and Fc-mediated effects.

ABSTRACT: Although substantial progress has been made with Ebola virus (EBOV) vaccine measures, the immune correlates of vaccine-mediated protection remain uncertain. Here, five mucosal vaccine vectors based on human and avian paramyxoviruses provided nonhuman primates with varying degrees of protection, despite expressing the same EBOV glycoprotein (GP) immunogen. Each vaccine produced antibody responses that differed in Fc-mediated functions and isotype composition, as well as in magnitude and coverage toward GP and its conformational and linear epitopes. Differences in the degree of protection and comprehensive characterization of the response afforded the opportunity to identify which features and functions were elevated in survivors and could therefore serve as vaccine correlates of protection.

SUBMITTER: Meyer M 

PROVIDER: S-EPMC8675601 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature