The relation between the gut microbiome and osteoarthritis: A systematic review of literature.

ABSTRACT:

Background

Along with mechanical and genetic factors, emerging evidence suggests that the presence of low-grade inflammation has a role in the pathogenesis of osteoarthritis (OA) and seems to be related to the microbiome composition of the gut.

Purpose

To provide evidence whether there is clinical or preclinical evidence of gut-joint axis in the pathogenesis and symptoms of OA.

Methods

An extensive review of the current literature was performed using three different databases. Human, as well as animal studies, were included. The risk of bias was identified using ROBINS and SYRCLE tools, while the quality of evidence was assessed using GRADE and CAMADARES criteria.

Results

A total of nineteen articles were included. Multiple animal studies demonstrated that both

SUBMITTER: Chisari E 

PROVIDER: S-EPMC8675674 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature