Phyto-fabricated silver nanoparticles inducing microbial cell death via reactive oxygen species-mediated membrane damage.

ABSTRACT: Eco-friendly synthesis of the silver nanoparticles (AgNPs) has a number of advantages like simplicity, biocompatibility, low toxicity in nature over their physical and chemical methods. In the present study, the authors report biosynthesized AgNPs using the root extract of the perennial plant 'Spiny gourd' (Momordica dioica) and investigated their anti-bacterial application with mechanistic approaches. Different biophysical techniques such as UV-Vis spectroscopy, FTIR, XRD, TEM, SAED, and DLS were employed for AgNPs characterization. The synthesized AgNPs were polydispersed, crystalline in nature, with anionic surface (-22.3 mV), spherical in shape with an average size of 13.2 nm. In addition, the AgNPs were stable in room temperature and in different biological buffers. The anti-bacterial

SUBMITTER: Naik LS 

PROVIDER: S-EPMC8675829 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature