Long non-coding RNAs and their targets as potential biomarkers in breast cancer.

ABSTRACT: Breast cancer is among the lethal types of cancer with a high mortality rate, globally. Its high prevalence can be controlled through improved analysis and identification of disease-specific biomarkers. Recently, long non-coding RNAs (lncRNAs) have been reported as key contributors of carcinogenesis and regulate various cellular pathways through post-transcriptional regulatory mechanisms. The specific aim of this study was to identify the novel interactions of aberrantly expressed genetic components in breast cancer by applying integrative analysis of publicly available expression profiles of both lncRNAs and mRNAs. Differential expression patterns were identified by comparing the breast cancer expression profiles of samples with controls. Significant co-expression networks were identified

SUBMITTER: Khalid M 

PROVIDER: S-EPMC8675856 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature