Serum and urinary biomarkers for early detection of acute kidney injury following Hypnale spp. envenoming.

ABSTRACT:

Background

Hump-nosed pit viper (HNV; Hypnale spp.) bites account for most venomous snakebites in Sri Lanka. Acute kidney injury (AKI) is the most serious systemic manifestation (1-10%) following HNV envenoming. We aimed to identify the value of functional and injury biomarkers in predicting the development of AKI early following HNV bites.

Methods

We conducted a prospective cohort study of patients with confirmed HNV envenoming presenting to two large tertiary care hospitals in Sri Lanka. Demographics, bite details, clinical effects, complications and treatment data were collected prospectively. Blood and urine samples were collected from patients for coagulation and renal biomarker assays on admission, at 0-4h, 4-8h, 8-16h and 16-24h post-bite and daily until discharge. Fo

SUBMITTER: Wijewickrama ES 

PROVIDER: S-EPMC8675918 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature