Perinatal Food Deprivation Modifies the Caloric Restriction Response in Adult Mice Through Sirt1.

ABSTRACT: Variations in the availability of nutritional resources in animals can trigger reversible adjustments, which in the short term are manifested as behavioral and physiological changes. Several of these responses are mediated by Sirt1, which acts as an energy status sensor governing a global genetic program to cope with changes in nutritional status. Growing evidence suggests a key role of the response of the perinatal environment to caloric restriction in the setup of physiological responses in adulthood. The existence of adaptive predictive responses has been proposed, which suggests that early nutrition could establish metabolic capacities suitable for future food-scarce environments. We evaluated how perinatal food deprivation and maternal gestational weight gain impact the transcriptiona

SUBMITTER: Pena-Villalobos I 

PROVIDER: S-EPMC8675943 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature