Investigating conformational changes of Prefoldin β1 as result of applying external mechanical force without any position constraint.

ABSTRACT: Manipulating molecular scale bio-nanorobots and influencing their behaviour is one of the major challenges of new researches. Many coiled coil type proteins are involved in important biological functions due to physical properties that make them ideal for both nanoscale manipulation and sensing. The Prefoldin beta subunit from Thermococcus strain KS-1(Prefoldin β1) is one of the possible proteins that can serve as a new bio-nano-actuator. Besides having a balanced architecture, Prefoldin β1 can exhibit a wide range of exclusive authorities. In this study, steered molecular dynamics simulation is applied along with the centre of mass pulling and analyses of Prefoldin β1 conformational changes to characterise some of those abilities. Thus, applying external mechanical force without an

SUBMITTER: Askarian M 

PROVIDER: S-EPMC8676137 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature