In silico and in vitro approaches to evaluate the bioactivity of Cassia auriculata L extracts.

ABSTRACT: The present study is an attempt to evaluate the in vitro anti-inflammatory and in silico anticancer potentials of the plant Cassia auriculata (CA). The aerial parts of CA were subjected to solvent extraction, and the extracts were fractionised by gas chromatography and mass spectrometry analysis for its phytochemical content. The antiinflammatory activity of the extracts were confirmed by the IC₅₀ value of 125.02 µg/ml for red blood cell membrane stabilisation and 195.7 µg/ml for inhibition of protein denaturation activity. The interaction of bioactive compounds of CA ethanol extract with target protein was predicted through molecular docking studies, serine/threonine-protein kinase B (AKT1), responsible for development and progression of lung cancer using A

SUBMITTER: Anitha R 

PROVIDER: S-EPMC8676251 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature