The Gut and Blood Microbiome in IgA Nephropathy and Healthy Controls.

ABSTRACT:

Background

IgA nephropathy (IgAN) has been associated with gut dysbiosis, intestinal membrane disruption, and translocation of bacteria into blood. Our study aimed to understand the association of gut and blood microbiomes in patients with IgAN in relation to healthy controls.

Methods

We conducted a case-control study with 20 patients with progressive IgAN, matched with 20 healthy controls, and analyzed bacterial DNA quantitatively in blood using 16S PCR and qualitatively in blood and stool using 16S metagenomic sequencing. We conducted between-group comparisons as well as comparisons between the blood and gut microbiomes.

Results

Higher median 16S bacterial DNA in blood was found in the IgAN group compared with the healthy controls group (7410 versus 6030 16S rDNA co

SUBMITTER: Shah NB 

PROVIDER: S-EPMC8676391 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature