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ABSTRACT: Background
It is unknown whether lung-protective ventilation is applied in burn patients and whether they benefit from it. This study aimed to determine ventilation practices in burn intensive care units (ICUs) and investigate the association between lung-protective ventilation and the number of ventilator-free days and alive at day 28 (VFD-28).Methods
This is an international prospective observational cohort study including adult burn patients requiring mechanical ventilation. Low tidal volume (V T) was defined as V T ≤ 8 mL/kg predicted body weight (PBW). Levels of positive end-expiratory pressure (PEEP) and maximum airway pressures were collected. The association between V T and VFD-28 was analyzed using a competing risk model. Ventilation settings were presented for all patients, focusing on the first day of ventilation. We also compared ventilation settings between patients with and without inhalation trauma.Results
A total of 160 patients from 28 ICUs in 16 countries were included. Low V T was used in 74% of patients, median V T size was 7.3 [interquartile range (IQR) 6.2-8.3] mL/kg PBW and did not differ between patients with and without inhalation trauma (p = 0.58). Median VFD-28 was 17 (IQR 0-26), without a difference between ventilation with low or high V T (p = 0.98). All patients were ventilated with PEEP levels ≥5 cmH2O; 80% of patients had maximum airway pressures <30 cmH2O.Conclusion
In this international cohort study we found that lung-protective ventilation is used in the majority of burn patients, irrespective of the presence of inhalation trauma. Use of low V T was not associated with a reduction in VFD-28.Trial registration
Clinicaltrials.gov NCT02312869. Date of registration: 9 December 2014.
SUBMITTER: Schultz MJ
PROVIDER: S-EPMC8676707 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Schultz Marcus J MJ Horn Janneke J Hollmann Markus W MW Preckel Benedikt B Glas Gerie J GJ Colpaert Kirsten K Malbrain Manu M Neto Ary Serpa AS Asehnoune Karim K de Abreu Marcello Gamma MG Martin-Loeches Ignacio I Pelosi Paolo P Sjöberg Folke F Binnekade Jan M JM Cleffken Berry B Juffermans Nicole P NP Knape Paul P Loef Bert G BG Mackie David P DP Enkhbaatar Perenlei P Depetris Nadia N Perner Anders A Herrero Eva E Cachafeiro Lucia L Jeschke Marc M Lipman Jeffrey J Legrand Matthieu M Horter Johannes J Lavrentieva Athina A Glas Gerie G Kazemi Alex A Guttormsen Anne Berit AB Huss Frederik F Kol Mark M Wong Helen H Starr Therese T De Crop Luc L de Oliveira Filho Wilson W Manoel Silva Junior João J Grion Cintia M C CMC Jeschke Marc G MG Burnett Marjorie M Mondrup Frederik F Ravat Francois F Fontaine Mathieu M Asehoune Karim K Floch Renan Le RL Jeanne Mathieu M Bacus Morgane M Chaussard Maïté M Lehnhardt Marcus M Mikhail Bassem Daniel BD Gille Jochen J Sharkey Aidan A Trommel Nicole N Reidinga Auke C AC Vieleers Nadine N Tilsley Anna A Onarheim Henning H Bouza Maria Teresa MT Agrifoglio Alexander A Fredén Filip F Palmieri Tina T Painting Lynda E LE
Burns & trauma 20211216
<h4>Background</h4>It is unknown whether lung-protective ventilation is applied in burn patients and whether they benefit from it. This study aimed to determine ventilation practices in burn intensive care units (ICUs) and investigate the association between lung-protective ventilation and the number of ventilator-free days and alive at day 28 (VFD-28).<h4>Methods</h4>This is an international prospective observational cohort study including adult burn patients requiring mechanical ventilation. L ...[more]