Constitutive and variable 2'-O-methylation (Nm) in human ribosomal RNA.

ABSTRACT: Epitranscriptomic modifications of stable RNAs are dynamically regulated and specific profiles of 2'-O-methylation in rRNA have been associated with distinct cancer types. However, these observations pointed out the existence of at least two distinct groups: a rather large group with constitutive rRNA Nm residues exhibiting a stable level of methylation and a more restricted set of variable modifications, giving rise to the concept of 'specialized ribosomes'. These heterogeneous ribosomes can modulate their translational properties and be key regulatory players, depending on the physiological state of the cell. However, these conclusions were drawn from a limited set of explored human cell lines or tissues, mostly related to cancer cells of the same type. Here, we report a comprehensive an

SUBMITTER: Motorin Y 

PROVIDER: S-EPMC8677024 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature