Anticancer drug-induced life-threatening ventricular arrhythmias: a World Health Organization pharmacovigilance study.

ABSTRACT:

Aims

With the explosion of anticancer drugs, an emerging concern is the risk for drug-induced sudden death (SD) via ventricular arrhythmias (VA).

Methods and results

We used the international pharmacovigilance database VigiBase (n = 18 441 659 reports) to compare drug-induced long QT (diLQT, n = 18 123) and VA (n = 29 193) including torsade de pointes (TdP, n = 8163) reporting for 663 anticancer drugs vs. all other drugs until 01/01/2019. The analysis used the 95% lower-end credibility interval of the information component (IC025), an indicator for disproportionate Bayesian reporting; significant when IC025 >0. There were 2301 reports (13.8% fatal) for 40 anticancer drugs significantly associated with diLQT (with 27 also associated with VA or SD) and 9 drugs associated with

SUBMITTER: Salem JE 

PROVIDER: S-EPMC8677441 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature