Emergence and Transmission of Daptomycin and Vancomycin-Resistant Enterococci Between Patients and Hospital Rooms.

ABSTRACT:

Background

Vancomycin-resistant enterococci (VRE) are a major cause of morbidity and mortality in immunocompromised patients. Tracking the dissemination of VRE strains is crucial to understand the dynamics of emergence and spread of VRE in the hospital setting.

Methods

Whole genome sequencing (WGS) and phylogenetic analyses were performed to identify dominant VRE strains and potential transmission networks between 35 patients with VRE-positive rectal swabs and their rooms (main rooms and bathrooms) on the leukemia (LKM) and the hematopoietic cell transplant (HCT) floors. Sequence types (STs), drug resistance genes, and patients' outcomes were also determined.

Results

A total of 89 VRE strains grouped into 10 different STs, of which newly described STs were isolated fr

SUBMITTER: El Haddad L 

PROVIDER: S-EPMC8677550 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature