Rapid detection of platelet inhibition and dysfunction in traumatic brain injury: A prospective observational study.

ABSTRACT:

Background

Rapid platelet function testing is frequently used to determine platelet function in patients with traumatic intracranial hemorrhage (tICH). Accuracy and clinical significance of decreased platelet response detected by these tests is not well understood. We sought to determine whether VerifyNow and whole blood aggregometry (WBA) can detect poor platelet response and to elucidate its clinical significance for tICH patients.

Methods

We prospectively enrolled patients with isolated tICH between 2018 and 2020. Demographics, medical history, injury characteristics, and patient outcomes were recorded. Platelet function was determined by VerifyNow and WBA testing at the time of arrival to the trauma bay and 6 hours later.

Results

A total of 221 patients were enrol

SUBMITTER: Alvikas J 

PROVIDER: S-EPMC8677601 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature