HIPEC-Induced Acute Kidney Injury: A Retrospective Clinical Study and Preclinical Model.

ABSTRACT:

Background

Hyperthermic intraperitoneal chemotherapy (HIPEC) combined with cytoreductive surgery (CRS) is the treatment of choice for selected patients with peritoneal malignancies. HIPEC is accompanied by moderate-to-high patient morbidity, including acute kidney injury. The significance of nephrotoxic agents such as cisplatin versus hyperthermia in HIPEC-induced nephrotoxicity has not been defined yet.

Patients and methods

A total of 153 patients treated with HIPEC were divided into groups with (AKI+) and without (AKI-) kidney injury. Laboratory parameters and data concerning patient demographics, underlying disease, surgery, complications, and HIPEC were gathered to evaluate risk factors for HIPEC-induced AKI. A preclinical mouse model was applied to assess the significan

SUBMITTER: Liesenfeld LF 

PROVIDER: S-EPMC8677640 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature