A meta-analysis of XRCC1 single nucleotide polymorphism and susceptibility to gynecological malignancies.

ABSTRACT:

Background

Gynecological malignant tumor is a serious threat to women's health, cervical cancer, endometrial cancer and ovarian cancer are the most common. The eponymous protein encoded by the XRCC1 (X-ray repair cross complementation 1) gene is an important functional protein in the process of single-stranded DNA damage. Non-synonymous mutations of XRCC1 gene cause amino acid sequence changes that affect protein function and DNA repair ability, and may affect the interaction with other DNA repair proteins, leading to increased risk of tumor development. Many studies have assessed the association between XRCC1 gene polymorphism and the risk of cancer in the female reproductive system, but the results have been inconclusive. In this study, the relationship between XRCC1 Arg399Gln, A

SUBMITTER: Zhang XQ 

PROVIDER: S-EPMC8677953 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature