ANKRD1 and SPP1 as diagnostic markers and correlated with immune infiltration in biliary atresia.

ABSTRACT:

Abstract

The diagnosis of biliary atresia (BA) remains a clinical challenge, reliable biomarkers that can easily distinguish BA and other forms of intrahepatic cholestasis (IC) are urgently needed.Differentially expressed genes were identified by R software. The least absolute shrinkage and selection operator regression and support vector machine algorithms were used to filter the diagnostic biomarkers of BA. The candidate biomarkers were further validated in another independent cohort of patients with BA and IC. Then CIBERSORT was used for estimating the fractions of immune cell types in BA. Gene set enrichment analyses were conducted and the correlation between diagnostic genes and immune cells was analyzed.A total of 419 differentially expressed genes in BA were detected and 2 g

SUBMITTER: Kong M 

PROVIDER: S-EPMC8678012 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature