Seizures' impact on cognition and quality of life in childhood cancer survivors.

ABSTRACT:

Background

The objective of this study was to determine the impact of seizure-related factors on neurocognitive, health-related quality of life (HRQOL), and social outcomes in survivors of childhood cancer.

Methods

Survivors of childhood cancer treated at St. Jude Children's Hospital (n = 2022; 48.3% female; median age, 31.5 years; median time since diagnosis, 23.6 years) completed neurocognitive testing and questionnaires. The presence, severity, resolution, and treatment history of seizures were abstracted from medical records. Adjusting for the age at diagnosis, sex, and prior cancer therapy, multivariable models examined the impact of seizures on neurocognitive and HRQOL outcomes. Mediation analyses were conducted for social outcomes.

Results

Seizures were identif

SUBMITTER: Phillips NS 

PROVIDER: S-EPMC8678188 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature