Critical windows of perinatal particulate matter (PM_2.5) exposure and preadolescent kidney function.

ABSTRACT: Air pollution exposure, especially particulate matter ≤2.5 μm in diameter (PM_2.5), is associated with poorer kidney function in adults and children. Perinatal exposure may occur during susceptible periods of nephron development. We used distributed lag nonlinear models (DLNMs) to examine time-varying associations between early life daily PM_2.5 exposure (periconceptional through age 8 years) and kidney parameters in preadolescent children aged 8-10 years. Participants included 427 mother-child dyads enrolled in the PROGRESS birth cohort study based in Mexico City. Daily PM_2.5 exposure was estimated at each participant's residence using a validated satellite-based spatio-temporal model. Kidney function parameters included estimated glomerular filtration rate

SUBMITTER: Rosa MJ 

PROVIDER: S-EPMC8678189 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature