Longitudinal Data Discontinuity in Electronic Health Records and Consequences for Medication Effectiveness Studies.

ABSTRACT: Electronic health record (EHR) discontinuity (i.e., receiving care outside of the study EHR system), can lead to information bias in EHR-based real-world evidence (RWE) studies. An algorithm has been previously developed to identify patients with high EHR-continuity. We sought to assess whether applying this algorithm to patient selection for inclusion can reduce bias caused by data-discontinuity in four RWE examples. Among Medicare beneficiaries aged >=65 years from 2007 to 2014, we established 4 cohorts assessing drug effects on short-term or long-term outcomes, respectively. We linked claims data with two US EHR systems and calculated %bias of the multivariable-adjusted effect estimates based on only EHR vs. linked EHR-claims data because the linked data capture medical information reco

SUBMITTER: Joshua Lin K 

PROVIDER: S-EPMC8678205 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature