Photoluminescence-Based Bioassay With Cysteamine-Capped TiO₂ Nanoparticles for the Selective Recognition of N-Acyl Homoserine Lactones.

ABSTRACT: Currently available diagnostic procedures for infections are laborious and time-consuming, resulting in a substantial financial burden by increasing morbidity, increased costs of hospitalization, and mortality. Therefore, innovative approaches to design diagnostic biomarkers are imperative to assist in the rapid and sensitive diagnosis of microbial infections. Acyl homoserine lactones (AHLs) are ubiquitous bacterial signaling molecules that are found to be significantly upregulated in infected sites. In this pioneering work, we have developed a simple photoluminescence-based assay using cysteamine-capped titanium oxide (TiO₂) nanoparticles for AHL detection. The PL intensity variation of the oxygen defect state of TiO₂ was used for the biosensing measurements. The bio

SUBMITTER: Vasudevan S 

PROVIDER: S-EPMC8678280 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature