Prenatal maternal phthalate exposures and trajectories of childhood adiposity from four to twelve years.

ABSTRACT:

Background/aim

Adiposity trajectories reflect dynamic process of growth and may predict later life health better than individual measures. Prenatal phthalate exposures may program later childhood adiposity, but findings from studies examining these associations are conflicting. We investigated associations between phthalate biomarker concentrations during pregnancy with child adiposity trajectories.

Methods

We followed 514 mother-child pairs from the Mexico City PROGRESS cohort from pregnancy through twelve years. We measured concentrations of nine phthalate biomarkers in 2nd and 3rd trimester maternal urine samples to create a pregnancy average using the geometric mean. We measured child BMI z-score, fat mass index (FMI), and waist-to-height ratio (WHtR) at three study visi

SUBMITTER: Kupsco A 

PROVIDER: S-EPMC8678304 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature