Increased Plasma Hyaluronan Levels are Associated With Acute Traumatic Coagulopathy.

ABSTRACT:

Introduction

Acute traumatic coagulopathy (ATC) is an endogenous impairment in hemostasis that often contributes to early mortality after trauma. Endothelial glycocalyx damage is associated with trauma-induced coagulation abnormalities; however, the specific relationship between hyaluronan (HA), a key glycocalyx constituent, and ATC has not been evaluated.

Methods

We performed a secondary analysis of prospectively collected data from a recent study in which trauma patients (>18 years) admitted to our Level I trauma center with an ABC Score≥2 were enrolled. Partial thromboplastin time (PTT), international normalized ratio (INR), and thromboelastography (TEG) parameters were recorded at arrival. Injury characteristics and clinical outcomes were obtained. Plasma HA levels were

SUBMITTER: Walker SC 

PROVIDER: S-EPMC8678307 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature