Tunable and Practical Homogeneous Organic Reductants for Cross-Electrophile Coupling.

ABSTRACT: The syntheses of four new tunable homogeneous organic reductants based on a tetraaminoethylene scaffold are reported. The new reductants have enhanced air stability compared to current homogeneous reductants for metal-mediated reductive transformations, such as cross-electrophile coupling (XEC), and are solids at room temperature. In particular, the weakest reductant is indefinitely stable in air and has a reduction potential of -0.85 V versus ferrocene, which is significantly milder than conventional reductants used in XEC. All of the new reductants can facilitate C(sp²)-C(sp³) Ni-catalyzed XEC reactions and are compatible with complex substrates that are relevant to medicinal chemistry. The reductants span a range of nearly 0.5 V in reduction potential, which allows

SUBMITTER: Charboneau DJ 

PROVIDER: S-EPMC8678384 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature