Feasibility and Effect of Physiological-Based CPAP in Preterm Infants at Birth.

ABSTRACT: Background: Preterm infants are commonly supported with 5-8 cmH₂O CPAP. However, animal studies demonstrate that high initial CPAP levels (12-15 cmH₂O) which are then reduced (termed physiological based (PB)-CPAP), improve lung aeration without adversely affecting cardiovascular function. We investigated the feasibility of PB-CPAP and the effect in preterm infants at birth. Methods: Preterm infants (24-30 weeks gestation) were randomized to PB-CPAP or 5-8 cmH₂O CPAP for the first 10 min after birth. PB-CPAP consisted of 15 cmH₂O CPAP that was decreased when infants were stabilized (heart rate ≥100 bpm, SpO₂ ≥85%, FiO₂ ≤ 0.4, spontaneous breathing) to 8 cmH₂O with steps of ~2/3 cmH₂O/min. P

SUBMITTER: Martherus T 

PROVIDER: S-EPMC8678466 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature